Literature
PubMed
PubMed® comprises more than 37 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites.
Featured Bookshelf titles
Characteristics of Existing Asthma Self-Management Education Packages
Leas BF, Tipton K, Bryant-Stephens T, et al.
LiverTox
Clinical and Research Information on Drug-Induced Liver Injury
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Literature databases
Bookshelf
Books and reports
MeSH
Ontology used for PubMed indexing
NLM Catalog
Books, journals and more in the NLM Collections
PubMed
Scientific and medical abstracts/citations
PubMed Central
Full-text journal articles
Data
Genes
Gene sequences and annotations used as references for the study of orthologs structure, expression, and evolution
Gene
Collected information about gene loci
GEO DataSets
Functional genomics studies
GEO Profiles
Gene expression and molecular abundance profiles
PopSet
Sequence sets from phylogenetic and population studies
Proteins
Protein sequences, 3-D structures, and tools for the study of functional protein domains and active sites
Conserved Domains
Conserved protein domains
Identical Protein Groups
Protein sequences grouped by identity
Protein
Protein sequences
Protein Family Models
Models representing hom*ologous proteins with a common function
Structure
Experimentally-determined biomolecular structures
BLAST
A tool to find regions of similarity between biological sequences
blastn
Search nucleotide sequence databases
blastp
Search protein sequence databases
blastx
Search protein databases using a translated nucleotide query
tblastn
Search translated nucleotide databases using a protein query
Primer-BLAST
Find primers specific to your PCR template
Genomes
Genome sequence assemblies, large-scale functional genomics data, and source biological samples
Assembly
Genome assembly information
BioCollections
Museum, herbaria, and other biorepository collections
BioProject
Biological projects providing data to NCBI
BioSample
Descriptions of biological source materials
Genome
Genome sequencing projects by organism
Nucleotide
DNA and RNA sequences
SRA
High-throughput sequence reads
Taxonomy
Taxonomic classification and nomenclature
Clinical
Heritable DNA variations, associations with human pathologies, and clinical diagnostics and treatments
ClinicalTrials.gov
Privately and publicly funded clinical studies conducted around the world
ClinVar
Human variations of clinical significance
dbGaP
Genotype/phenotype interaction studies
dbSNP
Short genetic variations
dbVar
Genome structural variation studies
GTR
Genetic testing registry
MedGen
Medical genetics literature and links
OMIM
Online mendelian inheritance in man
PubChem
Repository of chemical information, molecular pathways, and tools for bioactivity screening
BioAssays
Bioactivity screening studies
Compounds
Chemical information with structures, information and links
Pathways
Molecular pathways with links to genes, proteins and chemicals
Substances
Deposited substance and chemical information
News
Research news
NPR News JULY 14, 2024
8 things to know about the drug known as 'gas station heroin'
Bill Chappell
For decades, tianeptine was used to treat depression, even though no one knew how it worked. But it turns out it's a type of opioid, and the U.S. is facing a spike in abuse of "gas station heroin."
The Scientist JULY 10, 2024
Deleting a MicroRNA Cluster Reversed Biological Sex in Mice
Removing microRNA that caused conversion of male mice embryos into female sheds light on key noncoding elements in sex determination.
NPR News JULY 10, 2024
These monkeys were 'notoriously competitive' until Hurricane Maria wrecked their home
Ari Daniel
Rhesus macaques on Cayo Santiago are known for being intolerant, hierarchical and aggressive. After 2017's Hurricane Maria destroyed their home, the monkeys' society underwent surprising changes.
Recent blog posts
NCBI Insights JULY 16, 2024
NIH Genetic Testing Registry (GTR®) Annual Review Process Ensures High-quality Data
Do you rely on high-quality and up-to-date genetic test information from the NIH Genetic Testing Registry (GTR)? Laboratories are expected to regularly review their tests, lab contacts, and license data for accuracy. GTR is making the annual review process for submitters easier and more intuitive to ensure we provide you the most current information. Attention … Continue reading NIH Genetic Testing Registry (GTR®) Annual Review Process Ensures High-quality Data →
NCBI Insights JULY 15, 2024
RefSeq Release 225 Now Available!
Check out RefSeq release 225, now available onlineand from theFTPsite. You can access RefSeq data throughNCBI Datasets. What’s included in this release? As of July 8, 2024, this full release incorporates genomic, transcript, and protein data containing: 448,507,905 records 334,845,613 proteins 63,542,774 RNAs Sequences from 152,668 organisms The release is provided in several directories as … Continue reading RefSeq Release 225 Now Available! →
NIH Director's Blog JULY 11, 2024
Sequencing Technique Detects Earliest Signs of Genetic Mutations Underlying Cancer, Aging, and More
Every day, billions of cells in your body divide, each producing two daughter cells. It’s an essential process for your tissues and organs to renew themselves and remain healthy. To do it, cells must first duplicate their DNA to ensure that each daughter cell gets an accurate copy. In this process, mistakes are inevitably made. Most DNA errors are accurately fixed and do not lead to mutations. But when small errors akin to single-letter typos aren’t corrected, they can become permanent in a cell and multiplied with each subsequent cell division. Even cells that don’t divide, such as neurons in your brain, acquire damage and mutations in their DNA with age. As a result, your tissues contain collections of cells with distinct mutations that accumulate over time.While many of these small errors will show no obvious consequences, others can lead to cancer and other health conditions. Now, a new DNA sequencing technique, described in Nature and developed through research supported by NIH, promises to detect early DNA changes before they become permanent mutations in a cell’s genome. The method, called Hairpin Duplex Enhanced Fidelity Sequencing (HiDEF-seq), could advance our understanding of how and why mutations arise, with potentially important implications for our health. For example, the ability to identify signs that precede mutations may help predict a person’s health risks based on genetic predispositions, environmental exposures, or other factors.
